Associate Professor. Principal Investigator

Amsterdam UMC - location AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
+31205669111 c.yi@amsterdamumc.nl
Research Group

Publications

My publications in PubMed

My Google Scholar profile

Targeted PPARδ activation reprograms microglial immunometabolism and improves insulin sensitivity in HFD-fed rats. J Lipid Res. 2026. 67(2):100978.

Specific silencing of microglial gene expression in the rat brain by nanoparticle-based siRNA delivery. ACS Appl Mater Interfaces. 2022. 14(4):5066. 

Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity. Mol Psychiatry. 2021. 26(11):6336

The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1. Diabetes. 2019. 68(12):2223.

Lipoprotein lipase maintains microglial innate immunity in obesity. Cell Rep. 2017. 20 (13):3034.

TNFalpha drives mitochondrial stress in POMC neurons in obesity. Nat communs. 2017. 8:15143.

Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia. 2014. 62 (1):17.

Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest. 2012. 122 (1):153.

In vivo structural neuroimaging evaluation of the hypothalamus in Prader-Willi Syndrome sub-genotypes. J Rare Dis. 2026. 5(51).

Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus. Acta Neuropathol. 2025. 150(1):35.

Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion.  Acta Neuropathol. 2024. 147(1):64.

Reduction of oxytocin-containing neurons and enhanced glymphatic activity in the hypothalamic paraventricular nucleus of patients with type 2 diabetes mellitus. Acta Neuropathol Commun. 2023. 11(1):107.

The impact of antidiabetic treatment on human hypothalamic infundibular neurons and microglia. JCI Insight. 2020. (16):133868.

Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases. Neuroendocrinology. 2020. 111(3):263-272.

Loss of arginine vasopressin- and vasoactive intestinal polypeptide-containing neurons and glial cells in the suprachiasmatic nucleus of individuals with type 2 diabetes. Diabetologia. 2019. 62(11):2088-2093.